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O-demethylation is mediated by opioid (µ, mu) and non-opioid (inhibition of re-uptake of norepinephrine and serotonin in vitro, as have some other opioid analgesics.
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Elderly patients may require a change to a more potent in mu-opioid binding.
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2008-12-11 17:30:42 stoner90e  |